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Sulfasalazine (SAS) also acts on System X C - to inhibit the uptake of cystine [149], causing chronic depletion of glutathione in cells, thereby destroying the redox defense of cells, hindering tumor growth, and inducing tumors ferroptosis [149,150,151,152,153]

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In in vitro models on -cell lines (INS-1, MIN6), typical working concentrations are 1100 nM

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